Efficacious versus detrimental effects in treatment
If one can hypothesize a decrease in the number of outcomes as a result of a treatment or exposure in an a priori fashion (based on the literature, the opinions of peers and colleagues, and clinical expertise), then the epidemiological measure of interest is absolute risk reduction (ARR).
Inversely, if a hypothesis stipulated an increase in the risk of an outcome occurring, researchers will want to use absolute risk increase (ARI).
What type of treatment effect is expected as a result of treatment?
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