"Equally as good" treatment effects are established in equivalence trials
In inferential statistics and hypothesis testing, researchers are always trying to reject the null hypothesis to test for significant differences. With equivalence trials, the main goal is to NOT REJECT the null hypothesis, meaning the two treatments ARE EQUALLY GOOD* at what they are supposed to do.
The most important part of conducting equivalence trials is to specify the margin of equivalence a priori. The margin of equivalence is the area above and below the point on a continuum associated with the "gold standard" treatment that is clinically defined as being EQUALLY GOOD. Think of the margin of equivalence as the confidence interval wrapped around the cut-point on deciding if a treatment is beneficial.
If the new treatment being assessed in an equivalence trial and its respective 90% confidence interval falls WHOLLY within the margin of equivalence both above and below the cut-point for the "gold standard" treatment, then you can assume that the two treatments are EQUALLY GOOD or equivalent.
Click on the Equivalency Trial Calculator button to download a free calculator for equivalence trials.
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