Case-control designs are used to investigate rare outcomes and generate hypotheses
To conduct a case-control study, researchers choose a sample of people that have an outcome (cases) and then they choose a comparable sample of people that do not have the outcome (controls). The cases and controls are then compared on various risk factors associated with the outcome.
Case-control designs cannot generate measures of prevalence, nor can they infer causal effects, because of the lack of randomization. The researcher chooses how many people will be included in the study (leading to selection biases), so the prevalence in the entire population cannot be generated. There are also observation biases associated with using prior existing data that may or may not contain valid information.
Matching cases to controls adds extra complexity to case-control designs. It would be a tedious process to individually match each case to a comparable control. If at all possible, propensity score matching should be used to match cases to controls in the selection process. However, most times, researchers will compare the two groups on various demographic and prognostic factors to make sure that cases and controls are comparable at the group level.
Case-control studies can generate unadjusted odds ratios with 95% confidence intervals which provide a measure of strength of association between predictor and outcome variables. Between-subjects comparisons are often used with case-control designs.
Statistician Services for Professionals
Eric Heidel, Ph.D. will provide the following services for researchers, professionals, and organizations at $100/hour. Secure checkout is available with Stripe or PayPal.
- Statistical Analysis
- Research Design
- Sample Size Calculations
- Diagnostic Testing and Epidemiological Calculations
- Survey Design and Psychometrics
AppNotch: Convert this website into an Android and iOS app.
AppNotch team will notify you when your app gets approved in Google Play and Apple iTunes App Stores. Once your app goes live, enter your App Store URLs in this property window, publish your Weebly site and your app store icons will be visible in this page.
Please visit AppNotch.com FAQ to learn more about how to add App Store icons to your website, update your app, send Push notifications and more.
Professional Statistician For Hire!
Copyright © 2018 Scalë. All Rights Reserved. Patent Pending.