Acquiring clinical evidence
Acquiring clinical evidence means writing specific search queries and accessing high level evidence
If researchers are asking a background question as defined in the previous section of the EBM decision tree, then existing electronic and paper textbooks such as Harrison's, MDConsult, UpToDate, and Stat!Ref can be used.
If researchers are asking a foreground question as defined in the previous section of the EBM decision tree, then the foundation of their search terminology and subsequent search queries should be built around the research question as it is operationalized by the PICO mnemonic.
MeSH headings should be used in the literature search queries. To look up current MeSH headings, click on this link: http://www.nlm.nih.gov/mesh/
The 6S method for grading clinical evidence
Individual RCTs or observational studies
Synopses of studies
Synopses of syntheses
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**Straus SE, Glasziou P, Richardson WS, Haynes RB. Evidence-based medicine: How to practice and teach it. Edinburgh: Churchill Livingstone; 2011
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